A phytoconstituent 6-aminoflavone ameliorates lipopolysaccharide-induced oxidative stress mediated synapse and memory dysfunction via <i>p</i>-Akt/NF-kB pathway in albino mice

Abstract The current work examined the therapeutic potential of 6-aminoflavone (6AF) against mouse model-based oxidative stress-driven synaptic and memory impairment caused by lipopolysaccharides (LPSs). In brains experimental mice, LPS administration for 3 weeks significantly increased stress inhibiting antioxidant enzymes, including superoxide dismutase, peroxidase, catalase, glutathione, upregulating lipid peroxidase. Male albino mice were arbitrarily divided into four groups (1) Control, (2) treated (250 µg/kg, weeks), (3) plus 6AF (30 mg/kg 2 (4) weeks). Different enzyme assays, behavior tasks, western blotting technique used to test potentials this 6AF. Remarkably, dosage reversed activities enzymes reduced neuroinflammation in adult mice. Additionally, 6HF also improved synapse (both pre- post-proteins) restored impaired LPS. short, these findings propose that is a natural, non-toxic, potent agent treat neurodegenerative diseases.